Vielmetter Los Angeles was established in 2000 to present work by artists from a diverse range of genders and cultural backgrounds, many of whom are engaged in a rigorously conceptual practice. In 2019, the gallery expanded from Culver City to downtown Los Angeles.
 

Many artists have been represented from the beginning of their careers. The gallery presented the first solo exhibitions of Edgar Arceneaux, Rodney McMillian, and Wangechi Mutu, as well as the first Los Angeles solo exhibitions of Amy Sillman and Mickalene Thomas. Vielmetter Los Angeles has developed the careers of Math Bass, Andrea Bowers, Nicole Eisenman, Charles Gaines, Karl Haendel, Pope.L, Hugo McCloud, Elizabeth Neel, and more recently, April Bey, Sam Levi Jones, Deborah Roberts, and Robert Pruitt.