David B. Smith Gallery is committed to presenting intelligent and culturally relevant exhibitions in its Denver location, featuring the region’s most important emerging talent alongside internationally recognized artists. Through its curatorial program, participation in art fairs, and extensive media coverage in publications such as Artforum, Art in America and ARTnews, David B. Smith Gallery has cultivated a strong national and international audience. The New York Times hailed the gallery as offering "an exciting contrast of cutting edge works" and The Denver Post declared that it is "the premier commercial space" in Denver. The gallery also maintains an active publishing division, which produces exhibition catalogues and editions.

David B. Smith Gallery is a member of the New Art Dealers Alliance (NADA).